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- Title
Endothelin A Receptors Expressed in Glomeruli of Renal Transplant Patients May Be Associated with Antibody-Mediated Rejection.
- Authors
Nowańska, Katarzyna; Banasik, Mirosław; Donizy, Piotr; Kościelska-Kasprzak, Katarzyna; Zmonarski, Sławomir; Letachowicz, Krzysztof; Kamińska, Dorota; Mazanowska, Oktawia; Augustyniak-Bartosik, Hanna; Tukiendorf, Andrzej; Chudiak, Anna; Dawiskiba, Tomasz; Hałoń, Agnieszka; Krajewska, Magdalena; Hau, Hans-Michael; Yaqoob, Magdi
- Abstract
Background: Non-human leukocyte antigen (HLA) anti-endothelin A receptor antibodies are presented as being potentially important, but the expression of the endothelin A receptor in glomeruli (ETA receptor (g+)) has not yet been described. We decided to evaluate the presence and relevance of the ETA receptor in for-cause renal transplant biopsies. The aim of our study was to evaluate the immunoreactivity of the ETA receptor and its significance in patients who underwent a renal transplant biopsy due to the deterioration of transplant function, with detailed characterization of staining in glomeruli. Methods: The immunohistochemical expression of ETA receptor (ETAR) was analyzed in renal transplant biopsies. Microscopic evaluation was performed on paraffin sections in glomeruli. The analysis was performed using a two-step scale (0: lack of ETAR expression; 1: the presence of ETAR expression—mild to moderate immunoreactivity). Results: We analyzed 149 patients who underwent renal allograft biopsy after renal transplantation. Positive staining of ETA receptors in glomeruli (ETA receptor (g+)) was noticed in 13/149 (8.7%) patients. Five of these 13 (38.5%) patients with ETA receptor (g+) developed antibody-mediated rejection (AMR), while 13 of the remaining 136 (9.5%) ETA receptor (g-) patients developed AMR (p = 0.0022). Graft loss was noticed in all but one ETA receptor (g+) patient with AMR (4/5; 80%), but only in 2/13 (15%) ETA receptor (g-) patients with AMR (p = 0.009) during the first year after biopsy. Conclusions: The expression of endothelin A receptors in glomeruli seems to be a potentially important feature in the diagnosis of damage during antibody-mediated rejection. It may help to identify patients at a higher risk of allograft rejection and injury.
- Subjects
ENDOTHELIN receptors; KIDNEY transplantation; RENAL biopsy; RECEPTOR antibodies; DIAGNOSIS
- Publication
Journal of Clinical Medicine, 2021, Vol 10, Issue 3, p422
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm10030422