The article describes the case of a 70-year-old female patient with a history of chronic postmastectomy lymphoedema and who was diagnosed with Stewart-Treves syndrome. The diagnosis was confirmed after the patient was subjected to physical examination of the chronically lymphoedematous skin with multiple hyperkeratotic nodules, fissures and papules and biopsy. The patient died after palliative amputation and development of regional and distant metastasis.