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- Title
Association of respiratory viruses with serum metabolome in infants with severe bronchiolitis.
- Authors
Stewart, Christopher J.; Mansbach, Jonathan M.; Piedra, Pedro A.; Toivonen, Laura; Camargo, Carlos A.; Hasegawa, Kohei
- Abstract
Bronchiolitis is the leading cause of infant hospitalizations in the United States.[1] Two distinct viruses - respiratory syncytial virus (RSV) and rhinovirus (RV) - account for most cases of severe bronchiolitis (ie, bronchiolitis requiring hospitalization).[1] Although bronchiolitis is traditionally discussed as a single entity and currently available treatment does not vary by viral etiology,[2] emerging evidence suggests heterogeneity in the pathobiology of bronchiolitis by infecting virus. GLO:FS1/01dec19:pai13101-fig-0001.jpg PHOTO (COLOR): Association of respiratory syncytial virus (RSV)-only and rhinovirus (RV)-only bronchiolitis with serum metabolomic profile. Similar to the OPLS-DA, the unsupervised clustering of 20 most significant metabolites separated infants with RSV-only bronchiolitis from those with RV-only bronchiolitis (Figure B). Data based on serum metabolomics among infants with respiratory syncytial virus (RSV)-only (n = 79) compared to those with rhinovirus (RV)-only (n = 37) bronchiolitis.
- Subjects
BRONCHIOLITIS; INFANTS; RESPIRATORY syncytial virus infections; VIRUSES; LIQUID chromatography-mass spectrometry
- Publication
Pediatric Allergy & Immunology, 2019, Vol 30, Issue 8, p848
- ISSN
0905-6157
- Publication type
Article
- DOI
10.1111/pai.13101