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- Title
H elicobacter pylori infection and gastroesophageal reflux in children.
- Authors
Lupu, V. V.; Ignat, A.; Ciubotariu, G.; Ciubară, A.; Moscalu, M.; Burlea, M.
- Abstract
Some studies suggest that H elicobacter pylori ( H . pylori) infection would be a protective factor for the gastroesophageal reflux. The aim of this study was to explore this fact. A group of 72 children, admitted in a pediatric gastroenterology regional center in Northeast Romania, diagnosed with gastroesophageal reflux by 24-hour continuous esophageal pH monitoring (results were interpreted using the Boix- Ochoa score), underwent upper endoscopy with gastric biopsy to detect the presence of H . pylori by the rapid urease testing and for bacteriological and histologic examination. 19 children (26.39%) had H . pylori infection, while 53 (73.61%) did not. The grade of esophagitis was classified according to the Los Angeles classification system. Out of 47 children with esophagitis A, 16 (34.04%) had H . pylori infection, while out of the 25 children with esophagitis B, only 3 (12%) had H . pylori infection, with statistic significance (χ2 = 54.69, P << 0.05, 95% confidence interval [ CI]). Regarding the value of the Boix- Ochoa score, it appears that the presence of the H . pylori determines lower pH-metry scores ( F = 8.13, P = 0.0015, 95% CI). The presence of the H . pylori was not an important factor in the gastroesophageal reflux. On the other hand its relationship with esophagitis appears to be inverse ratio. The fact that the H . pylori presence is statistically greater in the grade A esophagitis could confirm the hypothesis that the bacteria would slow down the development of the esophagitis.
- Subjects
ROMANIA; GASTROESOPHAGEAL reflux diagnosis; HELICOBACTER pylori infections; JUVENILE diseases; GASTROENTEROLOGY; CONFIDENCE intervals
- Publication
Diseases of the Esophagus, 2016, Vol 29, Issue 8, p1007
- ISSN
1120-8694
- Publication type
Article
- DOI
10.1111/dote.12429