We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Aggressive subcutaneous trichoblastomas successfully treated with Mohs micrographic surgery.
- Authors
Owen, Joshua L; Liu, Wenhua; Croitoru, Alexandru; Krunic, Aleksandar L
- Abstract
Trichoblastoma is a rare cutaneous adnexal neoplasm demonstrating differentiation towards follicular germ.[1] Subtypes of trichoblastomas have been defined, most of which exhibit benign behaviour, but the rarer subcutaneous trichoblastoma variant can have aggressive features.[2] Histopathology of trichoblastoma often mimics basal cell carcinoma (BCC), and discriminating these is important as standard treatment options differ (Table S1). Immunohistochemistry showed CD10 diffusely positive in the stroma and restricted to periphery of tumour parenchyma, whereas Bcl-2 was partially positive in tumour islands (Fig. d,e). Bcl-2 often stains tumour cells moderately in classic trichoblastomas, while tumour cells of BCCs are highlighted strongly and diffusely.[5] There is one report of false-negative tumour margins with Mohs surgery for trichoblastoma.[1] One solution might be to utilise Immunohistochemistry to aid in margin identification for trichoblastoma.
- Subjects
MOHS surgery; BENIGN tumors; BASAL cell carcinoma
- Publication
Australasian Journal of Dermatology, 2019, Vol 60, Issue 3, pe249
- ISSN
0004-8380
- Publication type
Article
- DOI
10.1111/ajd.12983