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- Title
Local immune response to Mycobacterium lepraemurium in C3H and C57B1/6 mice.
- Authors
Lagrange, P. H.; Hurtrel, B.
- Abstract
Subcutaneous footpad inoculation of living M. lepraemurium (L.MLM) induced, in high responder C57B1/6 mice, a local granulomatous reaction associated with the production of effector cells which stopped the multiplication of bacilli in the draining popliteal node with the concurrent development of 24-48 hr delayed type hypersensitivity (DTH). The thymus-dependent local reaction did not occur after the injection of heat-killed M. lepraemurium (HK.MLM) or after the inoculation of L.MLM in nude mice. However, HK.MLM injection interfered with the onset of the local reaction and enhanced acid-fast bacteria (AFB) counts in the draining node. In low responder C3H mice, L.MLM produced a local and delayed footpad swelling but no restriction of bacilli multiplication in the draining lymph node was observed. This unresponsiveness was not due to an overloading of the inoculum dose since doses ranging from 3 × 104 to 3 × 107 MLM did not produce any granulomatous local reaction as in C57B1/6 mice. The injection of dead bacilli in the contralateral footpad of subcutaneously (s.c.) infected C3H mice revealed Arthus-like and 18-24 hr delayed reactions. When 106 L.MLM per mouse were injected intravenously (i.v.), systemic infection, measured in the spleen, was found to be less restricted in C57B1/5 than in C3H mice. Moreover, in C57B1/6 mice low doses of L.MLM injected i.v. delayed the local reaction at first, then enhanced footpad swelling and AFB counts in the draining nodes, indicating some acquired defect of peripheral immunity. When a high dose of L.MLM (2 × 108/mouse) was injected i.v., C57B1/6 mice died sooner than C3H mice, indicating certain discrepancies between local resistance and systemic susceptibility.
- Subjects
IMMUNE response; MYCOBACTERIUM leprae; ENDOCRINE glands; LYMPH nodes; ALLERGIES; LABORATORY rats
- Publication
Clinical & Experimental Immunology, 1979, Vol 38, Issue 3, p461
- ISSN
0009-9104
- Publication type
Article