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- Title
SERUM LYMPHOCYTOTOXINS IN INFLAMMATORY BOWEL DISEASE.
- Authors
Strickland, R. G.; Friedler, E. M.; Henderson, Carolyn A.; Wilson, I. D.; Williams, Jr., R. C.
- Abstract
Serum cold-reactive lymphocytotoxin (LCT) was detected in twenty-two of fifty- six (40%) patients with inflammatory bowel disease (EBD). The frequency of LCT detection was similar in Crohn's disease and ulcerative colitis. Cytotoxicity testing against T or B cell-enriched peripheral blood lymphocytes from normal donors, together with absorption experiments, indicated that LCT in IBD was reactive against determinants on both cell subpopulations. Reactivity against T cells from patients with common variable immunodeficiency was significantly less than with normal donor T cells. LCT in 1BD could not be related to prior allogeneic sensitization and its presence appeared to be unrelated to disease activity or drug therapy. No correlation was found between LCT and peripheral blood T- or B-cell numbers. The present findings suggest the need for further investigation of the role of infectious agents in the pathogenesis of IBD.
- Subjects
T cells; SERUM; BLOOD plasma; CROHN'S disease; ULCERATIVE colitis; INFLAMMATORY bowel diseases
- Publication
Clinical & Experimental Immunology, 1975, Vol 21, Issue 3, p384
- ISSN
0009-9104
- Publication type
Article