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- Title
Age changes in the rat temporomandibular joint articular disc: a biochemical study on glycosaminoglycan content.
- Authors
Okazaki, J.; Kamada, A.; Higuchi, Y.; Kanabayashi, T.; Sakaki, T.; Gonda, Y.
- Abstract
The temporomandibular joint (TMJ) articular discs were removed from female Sprague- Dawley rats 3, 5, 10, 32, 90 and 130 weeks of age. Glycosaminoglycans (GAGs) were extracted from the discs by heat treatment, alkali treatment and digestion with Pronase E, and purified by precipitation with cetylpyridinium chloride and ethanol. The concentration of total GAG was highest in the 3 week extracts and tended to decrease with age. Dermatan sulphate was the predominant GAG detected in all age groups along with chondroitin sulphate, hyaluronic acid and heparan sulphate. The disaccharides obtained from chondroitin sulphate were Δ -4S, ΔDi-6S and ΔDi-OS, with ΔDi-4S being the predominant isomer followed by ΔDi-6S for all ages of all the GAG examined. The concentration of chondroitin sulphate showed a decrease with age. Quantitative changes of GAG with age may be related to functional changes in TMJ discs.
- Subjects
TEMPOROMANDIBULAR joint; GLYCOSAMINOGLYCANS; DISACCHARIDES; ALCOHOL; HYALURONIC acid; DERMATAN sulfate
- Publication
Journal of Oral Rehabilitation, 1996, Vol 23, Issue 8, p536
- ISSN
0305-182X
- Publication type
Article
- DOI
10.1111/j.1365-2842.1996.tb00892.x