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- Title
Regular surveillance by imaging for early detection and better prognosis of hepatocellular carcinoma in patients infected with hepatitis C virus.
- Authors
Noda, Ikue; Kitamoto, Mikiya; Nakahara, Hideki; Hayashi, Ryohei; Okimoto, Tomoaki; Monzen, Yoshio; Yamada, Hiroyasu; Imagawa, Masaru; Hiraga, Nobuhiko; Tanaka, Junko; Chayama, Kazuaki
- Abstract
This study evaluated the usefulness of regular check-ups by ultrasonography and contrast-enhanced imaging for early detection of hepatocellular carcinoma (HCC) in a retrospective analysis. From April 2001 to March 2007, 240 consecutive patients with HCC who were infected with hepatitis C virus (HCV) were divided into three groups. Patients diagnosed with HCC by repeated imaging constituted Group A (surveillance group). Group B comprised patients in whom HCC was detected during scheduled doctor visits for liver disease or other diseases such as diabetes. Group C comprised non-screened patients. The prevalence of solitary tumors decreased from Group A through Group B to Group C (66, 48 and 24%, respectively, P < 0.001). The proportion of patients in stages I and II decreased from 83% (103/124) in Group A to 53% (42/79) in Group B and 24% (9/37) in Group C ( P < 0.001). The proportion of patients who were treated with curative procedures, such as resection or ablation, was highest at 80% (99/124) in Group A, and lower at 53% (42/79) in Group B and 27% (10/37) in Group C ( P < 0.001). The cumulative survival rate was better in Group A than B ( P < 0.05), and in Group B than C ( P < 0.001). Periodical medical check-ups without imaging did not necessarily detect early-stage disease, even when HCC-related markers including des-γ-carboxy prothrombin were tested. Regular surveillance with ultrasonography and contrast-enhanced imaging is useful for detecting early-stage HCC and increase chances for curative treatments in patients with HCV-related chronic liver disease.
- Subjects
LIVER cancer; HEPATITIS C virus; PROTHROMBIN; ULTRASONIC imaging; DISEASE prevalence
- Publication
Journal of Gastroenterology, 2010, Vol 45, Issue 1, p105
- ISSN
0944-1174
- Publication type
Article
- DOI
10.1007/s00535-009-0131-x