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- Title
High Neutrophil-to-Lymphocyte Ratio is a Significant Predictor of Cardiovascular and All-Cause Mortality in Patients Undergoing Peritoneal Dialysis.
- Authors
Lu, Xiangxue; Wang, Shixiang; Zhang, Guizhi; Xiong, Ruifang; Li, Han
- Abstract
<bold><italic>Background/Aims:</italic></bold> Chronic inflammation is associated with increased risk of cardiovascular death in patients with end-stage renal disease (ESRD). Although elevated neutrophil-to-lymphocyte ratio (NLR), a novel inflammatory marker, has been shown to predict cardiovascular disease and all-cause mortality in the general population, limited evidence is available for its role in ESRD. <bold><italic>Methods:</italic></bold> We enrolled 86 patients undergoing peritoneal dialysis (PD) for a 36-month follow-up to investigate the association between the NLR and arterial stiffness markers, namely, carotid-femoral pulse wave velocity (cfPWV) and carotid augmentation index (AIx), and mortality in PD patients. The primary endpoints were cardiovascular mortality and all-cause mortality. Kaplan–Meier curves were used to show the cumulative incidence of cardiovascular mortality and all-cause mortality. <bold><italic>Results:</italic></bold> High NLR was found to be a predictor of increased cfPWV (β = 1.150; <italic>P</italic> < 0.001) and AIx (β = 3.945; <italic>P</italic> < 0.001) in patients on PD. Patients with higher NLR had lower survival during follow-up. Kaplan–Meier curves showed that the cumulative incidences of both cardiovascular mortality and all-cause mortality were significantly higher in patients with NLR ≥ 4.5 (both <italic>P</italic> < 0.01). <bold><italic>Conclusion:</italic></bold> Our results suggest that high NLR is independently associated with arterial stiffness and predicts cardiovascular and all-cause mortality in PD patients.
- Subjects
CHRONIC kidney failure; PERITONEAL dialysis; CARDIOVASCULAR diseases; HEMODIALYSIS patients; NEUTROPHILS; PATIENTS
- Publication
Kidney & Blood Pressure Research, 2018, Vol 43, Issue 2, p490
- ISSN
1420-4096
- Publication type
Article
- DOI
10.1159/000488696