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- Title
Presynaptic HCN1 channels regulate Ca<sub>V</sub>3.2 activity and neurotransmission at select cortical synapses.
- Authors
Zhuo Huang; Lujan, Rafael; Kadurin, Ivan; Uebele, Victor N.; Renger, John J.; Dolphin, Annette C.; Shah, Mala M.
- Abstract
The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are subthreshold, voltage-gated ion channels that are highly expressed in hippocampal and cortical pyramidal cell dendrites, where they are important for regulating synaptic potential integration and plasticity. We found that HCN1 subunits are also localized to the active zone of mature asymmetric synaptic terminals targeting mouse entorhinal cortical layer III pyramidal neurons. HCN channels inhibited glutamate synaptic release by suppressing the activity of low-threshold voltage-gated T-type (CaV3.2) Ca2+ channels. Consistent with this, electron microscopy revealed colocalization of presynaptic HCN1 and CaV3.2 subunit. This represents a previously unknown mechanism by which HCN channels regulate synaptic strength and thereby neural information processing and network excitability.
- Subjects
PRESYNAPTIC receptors; CYCLIC nucleotides; NEURAL transmission; SYNAPSES; LABORATORY mice; NEURONS; GLUTAMIC acid; ELECTRON microscopy
- Publication
Nature Neuroscience, 2011, Vol 14, Issue 4, p478
- ISSN
1097-6256
- Publication type
Article
- DOI
10.1038/nn.2757