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- Title
Fulminant type 1 diabetes, an underrecognized and unique subtype of type 1 diabetes: A case series from Singapore.
- Authors
Tan, Sarah Ying Tse; Rama Chandran, Suresh; Yew, Jielin; Wong, Andy Jun‐Wei; Gardner, Daphne Su‐Lyn
- Abstract
Fulminant type 1 diabetes (FT1D) is a unique subtype of type 1 diabetes, characterized by acute absolute insulin deficiency, severe ketosis, and increased risk of hypoglycemia, glycemic variability and microvascular complications. Seven people with FT1D were identified from two tertiary centers in Singapore. Six were Chinese, the mean age was 35 years and all were lean (mean body mass index 20.3 kg/m2). All presented with diabetes ketosis or ketoacidosis and low C‐peptide. All but one had low glutamic acid decarboxylase antibodies. Nearly half had a missed/delayed diagnosis of FT1D. Three had frequent hypoglycemia, which improved after transition to continuous subcutaneous insulin infusion therapy. Individuals with FT1D experience unique diagnostic and management challenges associated with rapid absolute insulin deficiency. Greater awareness about this clinical entity is required.
- Subjects
SINGAPORE; TYPE 1 diabetes; ACETONEMIA; GLUTAMATE decarboxylase; SUBCUTANEOUS infusions; INFUSION therapy; BODY mass index
- Publication
Journal of Diabetes Investigation, 2024, Vol 15, Issue 6, p786
- ISSN
2040-1116
- Publication type
Case Study
- DOI
10.1111/jdi.14160