We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Efficacy of oral glucocorticoid and cyclosporine in a case of rituximab-refractory type B insulin resistance syndrome.
- Authors
Takei, Masahiro; Ishii, Hiroaki; Kawai, Yuko; Kato, Kosuke; Sekido, Takashi; Sato, Yoshihiko; Takeda, Teiji; Komatsu, Mitsuhisa
- Abstract
We describe a case of type B insulin resistance syndrome associated with systemic lupus erythematosus ( SLE) that was refractory to rituximab and successfully treated with a combination of oral glucocorticoids and cyclosporine. Prior to treatment, insulin resistance was severe, and application of a hyperinsulinemic euglycemic clamp was not possible despite the continuous intravenous infusion of insulin at a maximum rate of 9.0 mU/kg/min. The addition of cyclosporine to oral glucocorticoid therapy resulted in remission of insulin resistance. The combination of oral prednisolone and cyclosporine might be effective in treating type B insulin resistance syndrome, particularly in rituximab-resistant cases. However, nephrotoxicity is a particular concern for patients receiving long-term cyclosporine therapy.
- Subjects
GLUCOCORTICOIDS; CYCLOSPORINE; RITUXIMAB; METABOLIC syndrome; INSULIN resistance
- Publication
Journal of Diabetes Investigation, 2015, Vol 6, Issue 6, p734
- ISSN
2040-1116
- Publication type
Article
- DOI
10.1111/jdi.12337