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- Title
Influence of an M-Locus Difference on the Cellular and Humoral Immunological Reactivity Against H-2-Determined Antigens of the Mouse.
- Authors
Lilliehöök, B.; Blomgren, H.
- Abstract
Studies were initiated to determine whether an immune response to the Mls antigen of C3H mice could modify responses of CBA lymphocytes (H-2-compatible) to a foreign H-2 complex. CBA lympbocytes, partially tolerant to the C3Hdetermined Mls antigen, generated less effector cell activity against C57BI cells (H-2-incompatible) than lymph node cells from normal CBA donors when infused into irradiated C.3H X C57BI hosts. Effector cell activity was measured as the capacity of the cells in the irradiated spleens to inhibit CBA X C57B1 bone marrow proliferation. In contrast, immunization of CBA mice with C3H X C57BI cells yielded lower antibody titers against C57B1 cells than immunization with CBA X C57BI cells. Furthermore, preinjection of CBA mice with C3H X CBA cells strongly reduced the capacity of the animals to produce antibodies against C57B1 cells. Thus, these data support the conclusion that an immune response to a foreign Mls antigen may either enhance or suppress an immune response to H-2-incompatible cells.
- Subjects
IMMUNE response; LYMPH nodes; IMMUNOLOGY; IMMUNIZATION; LABORATORY mice; SPLEEN
- Publication
Scandinavian Journal of Immunology, 1977, Vol 6, Issue 9, p945
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1977.tb00415.x