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- Title
Isolation and Characterization of Amyloid-Related Serum Protein SAA as a Low Molecular Weight Protein.
- Authors
Anders, R. F.; Natvig, J. B.; Michaelsen, T. E.; Husby, G.
- Abstract
With direct immunoprecipitation or gel filtration under dissociating conditions, amyloid-related serum protein SAA has been isolated as a low molecular weight protein from the serum of two patients with rheumatoid arthritis but without known amyloidosis. The isolated protein SAA-showed antigenic identity and an amino acid composition that was similar, but not identical, with isolated fibril protein AA. Molecular weight estimations suggest that protein SAA is approximately 50% larger than protein AA and has a molecular weight of 14,000-15,000 daltons. Preliminary results indicate that protein SAA from a patient with amyloidosis has a similar small molecular weight subunit.
- Subjects
BLOOD proteins; AMYLOID; RHEUMATOID arthritis; AUTOIMMUNE diseases; IMMUNOLOGIC diseases; AUTOIMMUNITY; IMMUNE system
- Publication
Scandinavian Journal of Immunology, 1975, Vol 4, Issue 4, p397
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1975.tb02642.x