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- Title
The Value of Bronchoalveolar Lavage in the Diagnosis of Sputum Smear-NegativePulmonary Tuberculosis.
- Authors
Nikbakhsh, Novin; Bayani, Masomeh; Siadati, Sepideh
- Abstract
Background and Objectives: Sputum smear staining for acid-fast bacilli is initial approach to the diagnosis of pulmonary tuberculosis (PTB) but more than 50% of cases are sputum smear-negative. This study was aimed to investigate the diagnostic value of fiberoptic bronchoscopy (FOB) guided bronchoalveolar lavage (BAL) in patients suspected to have tuberculosis. Methods: This prospective cross-sectional study was carried out on 290 sputum smear-negative patients who were clinically suspicious for PTB in 2006-12. All patients were subjected to FOB and BAL, then BAL specimens stained and cultured. Results: Of the 290 patients, 173 cases (59.7%) were men and 117 cases (40.3%) were women with the age of 52.6±19.1 years (ranged 20-76 years). Of the total 290 BAL specimens, 110 specimens (38%) were positive for acid-fast bacilli. Sensitivity, specificity, PPV and NPV was 60%, 91%, 89% and 64%, respectively. Also, LR+ and LR- was 64.6% and 0.44%, respectively. Conclusion: FOB guided BAL is a reliable, rapid and useful method for establishing the diagnosis of smear negative PTB with minimal complications.
- Subjects
BRONCHOALVEOLAR lavage; SPUTUM examination; TUBERCULOSIS diagnosis; BRONCHOSCOPY; STAINS &; staining (Microscopy)
- Publication
Iranian Journal of Pathology, 2015, Vol 10, Issue 1, p35
- ISSN
1735-5303
- Publication type
Article