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- Title
Functions and Targets of miR-335 in Cancer.
- Authors
Ye, Lingling; Wang, Fen; Wu, Hao; Yang, Hui; Yang, Yan; Ma, Yajun; Xue, Aili; Zhu, Jing; Chen, Meili; Wang, Jinyan; Zhang, Quan an
- Abstract
MicroRNAs (miRNAs) are small non-coding RNAs (18∼ 25 nt in length) that act as master regulators of eukaryotic gene expression. They might play an oncogenic or tumor-suppressive role in multiple cancers. In recent decades, several studies have focused on the functions and mechanisms of miR-335 in cancer. The expression level of miR-335 in tissues and cells varies with cancer types, and miR-335 has been proposed as a potential biomarker for the prognosis of cancer. Besides, miR-335 may serve as an oncogene or tumor suppressor via regulating different targets or pathways in tumor initiation, development, and metastasis. Furthermore, miR-335 also influences tumor microenvironment and drug sensitivity. MiR-335 is regulated by various factors such as lncRNAs and microRNAs. In this review, we reveal the functions and targets of miR-335 in various cancers and its potential application as a possible biomarker in prognostic judgment and treatment of malignant tumors.
- Subjects
NON-coding RNA; BIOMARKERS; REGULATOR genes; TUMOR microenvironment; GENE expression
- Publication
OncoTargets & Therapy, 2021, Vol 14, p3335
- ISSN
1178-6930
- Publication type
Article
- DOI
10.2147/OTT.S305098