We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Follicular Lymphoma Presenting With Monoclonal IgM And MYD88 Mutation: A Case Report And Review Of The Literature.
- Authors
Xu, Linglong; Ding, Xiaoxiao; Ying, Limei; Zhang, Xiaochang; Lu, Nina
- Abstract
MYD88 mutation has been reported in various lymphomas, specifically in lymphoplasmacytic lymphoma. Yet, the mutation has not been reported in primary follicular lymphoma. Here, we present a 62-year-old male with follicular lymphoma who had an MYD88 L265P somatic mutation and monoclonal IgM gammopathy. He received four cycles of R-CHOP immunochemotherapy. Interim PET/CT evaluation indicated a state of stable disease (SD). Neither did serum IgM remarkably drop. He was then given a bortezomib-contained regimen which significantly reduced the level of serum IgM. To the best of our knowledge, this is the first report of follicular lymphoma with monoclonal IgM and MYD88 L265P mutation. The present case indicated bortezomib may benefit these patients.
- Subjects
LITERATURE reviews; SOMATIC mutation; MONOCLONAL gammopathies; WALDENSTROM'S macroglobulinemia; FOLLICULAR lymphoma
- Publication
OncoTargets & Therapy, 2019, Vol 12, p7833
- ISSN
1178-6930
- Publication type
Article
- DOI
10.2147/OTT.S211436