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- Title
Therapeutic role of olive leaves and hyperthermia on nitrosodiethylamine induced hepatocarcinogenesis in rats.
- Authors
Abdel-Gawa, Eman I.; Hassan, Amal I.
- Abstract
Aim of the study The present investigation was carried out to evaluate the effects of ethanolic olive leaves extract (OLE) alone or with whole body hyperthermia(WBH) in rat models of liver carcinogenesis, initiated by nitrosodiethylamine (NDEA) and promoted by phenobarbital(PB). ?ethods Liver cancer was induced by daily intraperitoneal injection of NDEA (200mg/kg) for three weeks. Two weeks after the last day of treatment with NDEA, PB was used with the aim to promote the carcinogenic effects for up to 6 weeks. OLE (200mg/kg) was administered intraperitoneally for 3 weeks either during or after the period of PB administration to hepatocellular carcinoma-bearing rats. After theexperimental period, serum and liver samples were collected for biochemical and histopathological analysis. Results On administration of the carcinogens, the levels of serum tumor markers and liver enzymes increased markedly, but were significantly lowered in the groups of OLE treatment, especially when OLE was administered during the period of PB administration. On the contrary, the albumin serum levels were decreased in the carcinogen-administered animals, which was improved up to normal levels in the OLE groups alone or with hyperthermia. The results were dependent on the stage of carcinogenesis, rather than the duration of the protective treatment. The histopathological observations of liver tissues were corresponding with the biochemical results and confirmed the difference between control and treated groups. Conclusions OLE may efficiently prevent the initiation step of carcinogenesis and modulate the development of NDEA-induced and PB-promoted hepatocellular carcinogenesis in rats.
- Subjects
OLIVE; LIVER cancer; FEVER; MYCOPLASMA; THERAPEUTIC use of antioxidants; LABORATORY rats; THERAPEUTICS
- Publication
Experimental Medicine, 2009, Vol 1, Issue 1, p8
- ISSN
1791-9967
- Publication type
Article