We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Asymmetric Aminations and Kinetic Resolution of Acyclic α‐Branched Ynones.
- Authors
He, Faqian; Shen, Guosong; Yang, Xiaoyu
- Abstract
Comprehensive Summary: An efficient method for asymmetric synthesis of acyclic α‐tertiary amine derivatives has been achieved through enantioselective aminations of α‐branched ynones with azodicarboxylates enabled by chiral phosphoric acid catalysis. Moreover, kinetic resolution of racemic starting material was realized under these conditions, which gave access to valuable enantioenriched α‐substituted ketones. A wide array of α‐aryl and alkyl‐substitutions, and the substituted alkynyl groups were well compatible with this method, producing both the amination products and the recovered ketones with good to high enantioselectivities.
- Subjects
TERTIARY amines; AMINATION; ASYMMETRIC synthesis; AMINE derivatives; PHOSPHORIC acid; KETONES; KINETIC resolution; CATALYSIS
- Publication
Chinese Journal of Chemistry, 2022, Vol 40, Issue 1, p15
- ISSN
1001-604X
- Publication type
Article
- DOI
10.1002/cjoc.202100514