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- Title
Inherited OKT4 epitope deficiency in a Chinese rhesus macaque.
- Authors
Liu, Ben‐Bo; Zhao, Ming‐Liang; Wang, Yun; Hu, Zheng‐Fei; Zheng, Yong‐Tang; Tian, Ren‐Rong
- Abstract
OKT4 is an important epitope of the CD4 molecular. Amino acid mutations in the CD4V3 region result in deficiency of the OKT4 epitope in human. Here, we firstly reported a case of hereditary deficiency of OKT4 epitope in an inbred Chinese rhesus macaque family. This epitope deficiency is due to cytosine to thymine transition and homozygote at the nucleotide position 793 of CD4 coding sequences, which leads to the replace of arginine at 265th position of CD4 molecule by tryptophan. The results reveal that OKT4 epitope deficiency is a very old phenotype and may be parentally inherited, and emphasize the importance of avoiding inbreeding in primate population breeding.
- Subjects
RHESUS monkeys; MACAQUES; CD4 antigen; AMINO acids; THYMINE; INBREEDING
- Publication
Journal of Medical Primatology, 2021, Vol 50, Issue 3, p185
- ISSN
0047-2565
- Publication type
Article
- DOI
10.1111/jmp.12526