We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Possible interaction of genotypes at cystathionine β-synthase and methylenetetrahydrofolate reductase (MTHFR) in neural tube defects.
- Authors
Speer, MC; Nye, J; McLone, D; Worley, G; Melvin, EC; Viles, KD; Franklin, A; Drake, C; Mackey, J; George, TM
- Abstract
Neural tube defects are a common, complex disorder with genetic and environmental components to risk. We investigated the previously reported interaction between homozygosity for the thermolabile variant at the methylenetetrahydrofolate reductase and heterozygosity for the 844ins68 allele at the cystathionine β-synthase loci in cases with lumbosacral myelomeningocele and their parents. Using control allele frequencies from our sample pooled with those published in the literature, we confirm a marginally significant interaction at these two loci. This finding suggests that additional, larger studies are warranted to investigate this possible interaction in more detail.
- Subjects
NEURAL tube defects; MYELOMENINGOCELE; HUMAN genetics; LUMBOSACRAL region; GENETICS; DISEASES
- Publication
Clinical Genetics, 1999, Vol 56, Issue 2, p142
- ISSN
0009-9163
- Publication type
Article
- DOI
10.1034/j.1399-0004.1999.560208.x