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- Title
Amplitude of low-frequency fluctuations in childhood-onset schizophrenia with or without obsessive-compulsive symptoms: a resting-state functional magnetic resonance imaging study.
- Authors
Yinghui Liang; Rongrong Shao; Zhiying Zhang; Xinmin Li; Longhao Zhou; Suqin Guo; Liang, Yinghui; Shao, Rongrong; Zhang, Zhiying; Li, Xinmin; Zhou, Longhao; Guo, Suqin
- Abstract
<bold>Introduction: </bold>Childhood-onset schizophrenia with obsessive-compulsive symptoms (COSO) and without obsessive-compulsive symptoms (COS) share considerable overlap in clinical features and genetic risk factors. However, the extent of brain functional abnormalities in COSO and COS is poorly understood.<bold>Material and Methods: </bold>A total of 51 first-episode childhood schizophrenic patients and 30 healthy age- and sex-matched controls were recruited. We used the Yale-Brown Obsessive Compulsive Scale to divide patients into COSO (n = 21) and COS (n = 30) groups. Resting-state functional magnetic resonance imaging images were obtained using a gradient-echo echo-planar imaging sequence. Voxel-based analysis of amplitude of low-frequency fluctuation (ALFF) maps between the two groups was performed.<bold>Results: </bold>The COS group showed significantly increased ALFF in the right caudate body, middle temporal gyrus and inferior parietal lobule (p < 0.05), while showing decreased ALFF in the left cerebellum posterior lobe (p < 0.05). The COSO group showed significantly increased ALFF in the left and right frontal lobe, cerebellum posterior lobe and precuneus (p < 0.05). When comparing the two groups, COSO showed significantly higher ALFF in the left cerebellum posterior lobe, frontal lobe, supramarginal gyrus, precuneus, right inferior frontal gyrus and medial frontal gyrus (p < 0.05). Interestingly, significantly lower ALFF was found in the right fusiform gyrus, corpus callosum and inferior parietal lobule in the group of patients with obsessive-compulsive symptoms (p < 0.05).<bold>Conclusions: </bold>Our findings increase the understanding of the pathophysiology of schizophrenia and may provide imaging evidence for early diagnosis of COSO or COS.
- Subjects
FUNCTIONAL magnetic resonance imaging; MAGNETIC resonance imaging; ECHO-planar imaging; FUSIFORM gyrus; CORPUS callosum
- Publication
Archives of Medical Science, 2019, Vol 15, Issue 1, p126
- ISSN
1734-1922
- Publication type
journal article
- DOI
10.5114/aoms.2018.73422