We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pharmacokinetics of 5-Aminofluorescein-Albumin, a Novel Fluorescence Marker of Brain Tumors During Surgery.
- Authors
Ding, Reinhard; Frei, Eva; Fardanesh, Mahmoudreza; Schrenk, Hans-Hermann; Kremer, Paul; Haefeli, Walter E.
- Abstract
In a phase I/II study, the new fluorescence marker 5-aminofluorescein covalently bound to human serum albumin (AFL-HSA) was intravenously administered to 10 patients with brain tumor 1 to 4 days before surgery, and AFL-HSA kinetics were determined to assess the optimum timing of dye administration. AFL-HSA was determined in serum and brain tissue by size exclusion chromatography with fluorescence detection. AFL-HSA disposition was quite similar to albumin kinetics with small volumes of distribution (volume of central compartment [Vc] = 2.4 L; volume of distribution [Vdβ] = 6.8 L; volume at steady state [Vss] = 5.9 L), a low clearance (mean Cl = 16.85 mL/h), and a long elimination half-life (mean T½β = 307 hours). Predicted peak concentrations in the peripheral compartment occurred at 80.9 hours, the time point of optimal fluorescence intensity observed in brain tumors during surgery.
- Subjects
GLIOMA treatment; BRAIN surgery; ANALYSIS of variance; BRAIN tumors; CLINICAL trials; FLUORESCENCE microscopy; GLIOMAS; HIGH performance liquid chromatography; INTRAVENOUS therapy; MAGNETIC resonance imaging; SERUM albumin; STAINS &; staining (Microscopy); TIME; DRUG administration
- Publication
Journal of Clinical Pharmacology, 2011, Vol 51, Issue 5, p672
- ISSN
0091-2700
- Publication type
Article
- DOI
10.1177/0091270010372626