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- Title
Effect of Antipsychotic Medications on Glucose and Lipid Levels.
- Authors
Chaggar, Parminder S.; Shaw, Steven M.; Williams, Simon G.
- Abstract
Severe mental illnesses, such as schizophrenia and bipolar affective disorder, are associated with excess cardiovascular morbidity and mortality. Cardiovascular risk in psychiatric disorders is partly related to antipsychotic therapy, especially second-generation or atypical antipsychotics. Some antipsychotic medications are associated with proatherogenic conditions including insulin resistance and dyslipidemia. In particular, olanzapine and clozapine have been consistently demonstrated to promote insulin resistance and dyslipidemia. Ziprasidone and amisulpiride may be associated with more favorable metabolic effects. Many of the published data relating to metabolic effects of anti-psychotics originate from retrospective studies. However, prospective randomized-controlled data are emerging, and the latest evidence is described here.
- Subjects
ANTIPSYCHOTIC agents; CLOZAPINE; GLUCOSE; INSULIN resistance; LIPIDS; LONGITUDINAL method; MEDLINE; ONLINE information services; PSYCHOSES; OLANZAPINE; SYSTEMATIC reviews; RANDOMIZED controlled trials; PHARMACODYNAMICS
- Publication
Journal of Clinical Pharmacology, 2011, Vol 51, Issue 5, p631
- ISSN
0091-2700
- Publication type
Article
- DOI
10.1177/0091270010368678