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- Title
Nicotinic Acetylcholine Receptors of PC12 Cells.
- Authors
Mussina, Kamilla; Toktarkhanova, Dana; Filchakova, Olena
- Abstract
Nicotinic acetylcholine receptors (nAChRs) have gained much attention in the scientific community since they play a significant role in multiple physiological and pathophysiological processes. Multiple approaches to study the receptors exist, with characterization of the receptors' functionality at a single cellular level using cell culturing being one of them. Derived from an adrenal medulla tumor, PC12 cells express nicotinic receptor subunits and form functional nicotinic receptors. Thus, the cells offer a convenient environment to address questions related to the functionality of the receptors. The review summarizes the findings on nicotinic receptors' expression and functions which were conducted using PC12 cells. Specific focus is given to α3-containing receptors as well as α7 receptor. Critical evaluation of findings is provided alongside insights into what can still be learned about nAChRs, using PC12 cells.
- Subjects
NICOTINIC acetylcholine receptors; CHOLINERGIC receptors; CELL receptors; NICOTINIC receptors; ADRENAL tumors
- Publication
Cellular & Molecular Neurobiology, 2021, Vol 41, Issue 1, p17
- ISSN
0272-4340
- Publication type
Article
- DOI
10.1007/s10571-020-00846-x