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- Title
Comparison of Immunogenicity Between Inactivated and Live Attenuated Hepatitis A Vaccines Among Young Adults: A 3-Year Follow-up Study.
- Authors
Xue-en Liu; Hai-ying Chen; Zheng Liao; Yisheng Zhou; Hairong Wen; Shihui Peng; Yan Liu; Rui Li; Jie Li; Hui Zhuang; Liu, Xue-en; Chen, Hai-ying; Liao, Zheng; Zhou, Yisheng; Wen, Hairong; Peng, Shihui; Liu, Yan; Li, Rui; Li, Jie; Zhuang, Hui
- Abstract
<bold>Unlabelled: </bold>A randomized clinical trial of hepatitis A vaccines (1 or 2 doses of inactivated vaccine [Healive] or 1 dose of live attenuated vaccine [Biovac]) was conducted among adults to evaluate seroprotection rates and geometric mean concentrations of antibody against hepatitis A virus for 36 months. High rates of seroprotection persisted for at least 36 months among adults who received 1 or 2 doses of inactivated hepatitis A vaccine but not among adults who received 1 dose of live attenuated hepatitis A vaccine. The long-term serial monitoring of immunogenicity induced by 1 dose of inactivated hepatitis A vaccine is needed to determine an effective alternative to a 2-dose schedule.<bold>Clinical Trials Registration: </bold>NCT01865968.
- Subjects
CHINA; IMMUNOGENETICS; HEPATITIS A vaccines; YOUNG adults; FOLLOW-up studies (Medicine); CLINICAL trials; FISHER exact test; ONE-way analysis of variance; HEPATITIS A; HEPATITIS viruses; LONGITUDINAL method; VACCINES; VIRAL antibodies; RANDOMIZED controlled trials; PREVENTION
- Publication
Journal of Infectious Diseases, 2015, Vol 212, Issue 8, p1232
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiv213