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- Title
Combination therapy with lysin CF-301 and antibiotic is superior to antibiotic alone for treating methicillin-resistant Staphylococcus aureus-induced murine bacteremia.
- Authors
Schuch, Raymond; Lee, Han M; Schneider, Brent C; Sauve, Karen L; Law, Christina; Khan, Babar K; Rotolo, Jimmy A; Horiuchi, Yuki; Couto, Daniel E; Raz, Assaf; Fischetti, Vincent A; Huang, David B; Nowinski, Robert C; Wittekind, Michael
- Abstract
Lysins are bacteriophage-derived enzymes that degrade bacterial peptidoglycans. Lysin CF-301 is being developed to treat Staphylococcus aureus because of its potent, specific, and rapid bacteriolytic effects. It also demonstrates activity on drug-resistant strains, has a low resistance profile, eradicates biofilms, and acts synergistically with antibiotics. CF-301 was bacteriolytic against 250 S. aureus strains tested including 120 methicillin-resistant S. aureus (MRSA) isolates. In time-kill studies with 62 strains, CF-301 reduced S. aureus by 3-log10 within 30 minutes compared to 6-12 hours required by antibiotics. In bacteremia, CF-301 increased survival by reducing blood MRSA 100-fold within 1 hour. Combinations of CF-301 with vancomycin or daptomycin synergized in vitro and increased survival significantly in staphylococcal-induced bacteremia compared to treatment with antibiotics alone (P < .0001). Superiority of CF-301 combinations with antibiotics was confirmed in 26 independent bacteremia studies. Combinations including CF-301 and antibiotics represent an attractive alternative to antibiotic monotherapies currently used to treat S. aureus bacteremia.
- Publication
Journal of Infectious Diseases, 2014, Vol 209, Issue 9, p1469
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jit637