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- Title
PANcreatic-DERived factor: Novel hormone PANDERing to glucose regulation
- Authors
Wilson, Camella G.; Robert-Cooperman, Claudia E.; Burkhardt, Brant R.
- Abstract
Abstract: PANcreatic-DERived factor (PANDER, FAM3B) is a member of the FAM3 family of cytokine molecules that were initially described in 2002. PANDER expression is primarily localized to the endocrine pancreas and is secreted from both pancreatic α and β-cells. Initial characterization of PANDER revealed a potential role in pancreatic islet apoptosis. However, recent animal models have indicated PANDER functions as a hormone by regulating glucose levels via interaction with both the liver and the endocrine pancreas. An understanding of the function of PANDER can further the insight into the mechanisms of glucose regulation and potentially provide additional therapeutic targets for the treatment of diabetes. This review details the supporting data demonstrating PANDER has a biological function in glycemic regulation.
- Subjects
ISLANDS of Langerhans; CYTOKINES; GLUCOSE; GENE expression; APOPTOSIS; TREATMENT of diabetes; ANIMAL models in research
- Publication
FEBS Letters, 2011, Vol 585, Issue 14, p2137
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2011.05.059