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- Title
The pedestrian watchmaker: Genetic clocks from engineered oscillators
- Authors
Cookson, Natalie A.; Tsimring, Lev S.; Hasty, Jeff
- Abstract
Abstract: The crucial role of time-keeping has required organisms to develop sophisticated regulatory networks to ensure the reliable propagation of periodic behavior. These biological clocks have long been a focus of research; however, a clear understanding of how they maintain oscillations in the face of unpredictable environments and the inherent noise of biological systems remains elusive. Here, we review the current understanding of circadian oscillations using Drosophila melanogaster as a typical example and discuss the utility of an alternative synthetic biology approach to studying these highly intricate systems.
- Subjects
SYNTHETIC biology; BIOLOGICAL rhythms; OSCILLATIONS; BIOLOGICAL systems; DROSOPHILA melanogaster; GENETICS; MOLECULAR biology
- Publication
FEBS Letters, 2009, Vol 583, Issue 24, p3931
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2009.10.089