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- Title
The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS
- Authors
Kadowaki, Takashi; Yamauchi, Toshimasa; Kubota, Naoto
- Abstract
Abstract: Adiponectin is an abundantly expressed adipokine in adipose tissue and has direct insulin sensitizing activity. A decrease in the circulating levels of adiponectin by interactions between genetic factors and environmental factors causing obesity has been shown to contribute to the development of insulin resistance, type 2 diabetes, metabolic syndrome and atherosclerosis. In addition to its insulin sensitizing actions, adiponectin has central actions in the regulation of energy homeostasis. Adiponectin enhances AMP-activated protein kinase activity in the arcuate hypothalamus via its receptor AdipoR1 to stimulate food intake and decreases energy expenditure. We propose a hypothesis on the physiological role of adiponectin: a starvation gene in the course of evolution by promoting fat storage on facing the loss of adiposity.
- Subjects
PROTEIN hormones; ADIPOSE tissues; TISSUES; INSULIN
- Publication
FEBS Letters, 2008, Vol 582, Issue 1, p74
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2007.11.070