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- Title
Rab cascades and tethering factors in the endomembrane system
- Authors
Markgraf, Daniel F.; Peplowska, Karolina; Ungermann, Christian
- Abstract
Abstract: Rab GTPases are key proteins that determine organelle identity and operate at the center of fusion reactions. Like Ras, they act as switches that are connected to a diverse network of tethering factors, exchange factors and GTPase activating proteins. Recent studies suggest that Rabs are linked to each other via their effectors, thus coordinating protein transport in the endomembrane system. Within this review, we will focus on selected examples that highlight these issues.
- Subjects
HYDROLASES; CONTROLLED fusion; PROTEINS; DEVELOPMENTAL biology
- Publication
FEBS Letters, 2007, Vol 581, Issue 11, p2125
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2007.01.090