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- Title
Psoriasis in the elderly: epidemiological and clinical aspects, and evaluation of patients with very late onset psoriasis.
- Authors
Phan, C.; Sigal, M. ‐ L.; Estève, E.; Reguiai, Z.; Barthélémy, H.; Beneton, N.; Maccari, F.; Lahfa, M.; Thomas ‐ Beaulieu, D.; Le Guyadec, T.; Vermersch ‐ Langlin, A.; Mery ‐ Bossard, L.; Pallure, V.; Kemula, M.; Labeille, B.; Beauchet, A.; Mahé, E.
- Abstract
Background: Age of the patients and age of onset of psoriasis may have an impact on the disease. There is little information about psoriasis in elderly patients. Objective: We evaluated epidemiological, clinical aspects, comorbidities and treatments of psoriasis in the elderly (>70 years) patients, and in patients with very late onset psoriasis (onset ≥ 70 years). Methods: This observational multicentre non-interventional study of adults with psoriasis was conducted in 29 departments of dermatology in France. A total of 2210 adults with psoriasis were included. Results: A total of 212 (9.5%) patients were elderly. This group had a higher frequency of females (P = 0.005), a later onset of the disease (P < 0.0001), a lower frequency of familial (P < 0.0001) and plaque psoriasis (P < 0.0001), but higher frequency of guttate and inverse psoriasis (P = 0.005). Hypertension, diabetes, dyslipidaemia, and major cardiovascular events (MACE) were more frequent in this group (P < 0.0001), but not tobacco (P < 0.0001). Systemic and biological therapies were used less frequently in the elderly group (P < 0.0001). Fifty-eight (2.7%) patients had late onset psoriasis. Patients with very late onset psoriasis were more frequently women (P = 0.02) and older (P < 0.0001), among elderly group. They had significantly less frequently familial (P < 0.0001) and plaque psoriasis (P < 0.0001), and were less often on systemic treatment including biological. Frequencies of comorbidities were not statically different but patients with 'early' onset psoriasis have a tendency (P < 0.5) to have higher frequencies of obesity, diabetes, dyslipidaemia, hypertension and MACE. Conclusion: This study highlights phenotypic features of psoriasis in elderly and in very late onset psoriasis. The management of these fragile patients remains poorly codified and needs further investigation.
- Subjects
PSORIASIS; EPIDEMIOLOGY; CLINICAL trials; HYPERTENSION; CARDIOVASCULAR diseases
- Publication
Journal of the European Academy of Dermatology & Venereology, 2016, Vol 30, Issue 1, p78
- ISSN
0926-9959
- Publication type
Article
- DOI
10.1111/jdv.12850