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- Title
Cervical human papillomavirus and HIV infection in women of child-bearing age in Abidjan, Côte d'Ivoire, 2010.
- Authors
Jaquet, A; Horo, A; Charbonneau, V; Ekouevi, D K; Roncin, L; Toure, B; Coffie, P; Minga, A; Sasco, A J; Garrigue, I; Fleury, H; Dabis, F
- Abstract
Background:We sought to document the association of Human immunodeficiency Virus (HIV) infection and immunodeficiency with oncogenic Human Papillomavirus (HPV) infection in women with no cervical neoplastic lesions identified through a cervical cancer screening programme in Côte d'Ivoire.Methods:A consecutive sample of women stratified on their HIV status and attending the national blood donor clinic or the closest HIV clinic was recruited during a cervical cancer screening programme based on the visual inspection. Diagnosis of HPV infection and genotype identification were based on the Linear Array; HPV test.Results:A total of 445 (254 HIV-positive and 191 HIV-negative) women were included. The prevalence of oncogenic HPV infection was 53.9% (95% confidence interval (CI) 47.9-59.9) in HIV-positive women and 33.7% (95% CI 27.1-40.3) in HIV-negative women (odds ratio (OR)=2.3 (95% CI 1.5-3.3)). In multivariate analysis, HIV-positive women with a CD4 count <200 cells mm3 or between 200 and 499 cells mm3 were more likely to harbour an oncogenic HPV compared with women with a CD4 count 500 cells mm3 with OR of 2.8 (95% CI 1.1-8.1) and 1.7 (95% CI 1.0-2.9), respectively.Conclusion:A high prevalence of oncogenic HPV was found in women with no cervical neoplastic lesions, especially in HIV-positive women. Despite antiretroviral use, immunodeficiency was a main determinant of the presence of oncogenic HPV.
- Subjects
ABIDJAN (Cote d'Ivoire); COTE d'Ivoire; PAPILLOMAVIRUSES; HIV infections; ONCOGENIC viruses; CERVICAL cancer; DISEASES in women
- Publication
British Journal of Cancer, 2012, Vol 107, Issue 3, p556
- ISSN
0007-0920
- Publication type
Article
- DOI
10.1038/bjc.2012.299