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- Title
Extra cellular water and increase in capillary permeability to albumin in overweight women with swelling syndrome.
- Authors
Valensi, P; L'Hermite, F; Behar, A; Sandre-Banon, D; Cohen-Boulakia, F; Attali, J R
- Abstract
OBJECTIVE: To evaluate extracellular water (ECW) in the recumbent and the upright position, in overweight and lean women with swelling syndrome, and to correlate the excess in ECW with an increase in capillary filtration of albumin (CFA). PATIENTS: Fifty-one women with a swelling syndrome were investigated, 26 of whom were overweight. MEASUREMENTS: ECW was measured by the biaelectrical impedance method, in the recumbent position and again after a pastural test which consisted of walking around for 30 min. CFA was studied by an isotopic test using 99m technetium-labelled albumin. RESULTS: ECW increased (>107% of the theoretical value) in 22 of the 26 overweight patients and 23 of the 25 lean patients. The CFA isotopic test was abnormal in half (11/22) of the overweight patients with increased ECW and in three of the four overweight patients with a normal ECW value. It was abnormal in 18 of the 23 lean patients with increased ECW and in the two lean patients with a normal ECW value. During the pastural test, a significant (by ≥4%) increase in ECW occurred in a higher proportion of overweight patients tested (14/22) than among the lean women tested (0/5; P=0.04). CONCLUSIONS: The swelling syndrome is indeed related to an increase in ECW in lean and overweight subjects and to a further increase in ECW after a pastural test only in the overweight patients. It is also associated with micracirculatary disorders in most of the lean patients who complain of swelling and in only half of the overweight patients with the same complaints, which suggests that other factors (e.g. hormonal disorders) may be involved in the overweight patients.
- Subjects
EDEMA; ALBUMINS; CAPILLARY permeability; OVERWEIGHT women
- Publication
International Journal of Obesity & Related Metabolic Disorders, 2000, Vol 24, Issue 1, p126
- ISSN
0307-0565
- Publication type
Article
- DOI
10.1038/sj.ijo.0801096