We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effect of long-term proton pump inhibitor administration on gastric mucosal atrophy: A meta-analysis.
- Authors
Zhong Li; Cong Wu; Ling Li; Zhaoming Wang; Haibin Xie; Xiaozhou He; Jin Feng
- Abstract
Background/Aims: Proton pump inhibitors (PPIs) are widely used for the treatment of acid-related gastrointestinal diseases. Recently, some studies have reported that PPIs can alter the gastric mucosal architecture; however, the relationship remains controversial. This meta-analysis study was designed to quantify the association between long-term PPI administration and gastric atrophy. Materials and Methods: A PubMed search was conducted to identify studies using the keywords proton pump inhibitors or PPI and gastric atrophy or atrophic gastritis; the timeframe of publication searched was up to May 2016. Heterogeneity among studies was tested with the Q test; odds ratios (OR) and 95% confidence intervals (CI) were calculated. P values were calculated by I2 tests and regarded as statistically significant when <0.05. Results: We identified 13 studies that included 1465 patients under long-term PPI therapy and 1603 controls, with a total gastric atrophy rate of 14.50%. There was a higher presence of gastric atrophy (15.84%; statistically significant) in PPI group compared to the control group (13.29%) (OR: 1.55, 95% CI: 1.00-2.41). Conclusions: The pooled data suggest that long-term PPI use is associated with increased rates of gastric atrophy. Large-scale multicenter studies should be conducted to further investigate the relationship between acid suppressants and precancerous diseases.
- Subjects
ATROPHY; ATROPHIC gastritis; CONFIDENCE intervals; GASTRIC mucosa; MEDLINE; META-analysis; ONLINE information services; SYSTEMATIC reviews; PROTON pump inhibitors; DESCRIPTIVE statistics; ODDS ratio; DISEASE risk factors
- Publication
Saudi Journal of Gastroenterology, 2017, Vol 23, Issue 4, p222
- ISSN
1319-3767
- Publication type
Article
- DOI
10.4103/sjg.SJG_573_16