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- Title
MORFAN syndrome: A rarity but a reality!
- Authors
Roy, Gourab; Sen, Sumit; Poddar, Shreya
- Abstract
Acanthosis nigricans (AN) describes clinically hyperpigmented skin, which most commonly affects the flexural areas such as axilla, groin and neck. It is usually a benign condition associated with obesity, insulin resistance, and hyperinsulinemia; endocrinopathy; or malignancy, in particular, gastrointestinal adenocarcinoma. It can also occur in association with various genetic syndromes involving various organ systems. Few such known syndromes are Berardinelli-Seip syndrome, Alström syndrome, Leprechaunism, and Bardet-Biedl syndrome. MORFAN syndrome, which associates mild mental retardation, pre- and post-natal overgrowth, remarkable facies and diffuse and widespread AN, is a rare entity.
- Subjects
ADENOCARCINOMA; AXILLA; ENDOCRINE diseases; GROIN; HYPERINSULINISM; INSULIN resistance; LAURENCE-Moon-Biedl syndrome; MARFAN syndrome; MELANOSIS; PEOPLE with intellectual disabilities; NECK; OBESITY; RARE diseases; GASTROINTESTINAL tumors; ALSTROM syndrome; LIPODYSTROPHY; HYPERPIGMENTATION; DONOHUE syndrome
- Publication
Indian Journal of Dermatology, 2019, Vol 64, Issue 3, p231
- ISSN
0019-5154
- Publication type
Article
- DOI
10.4103/ijd.IJD_160_19