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- Title
Selective effect of cyclosporine monotherapy for pure red cell aplasia not associated with granular lymphocyte-proliferative disorders.
- Authors
Yamada, Osamu; Motoji, Toshiko; Mizoguchi, Hideaki
- Abstract
Morphological characteristics of lymphocytes and the response to cyclosporine treatment have revealed some unique patients with pure red cell aplasia. Lymphocytes from these patients consisted mainly of non-granulated lymphocytes. All of the patients were successfully managed by cyclosporine monotherapy irrespective of prior treatment. A reduction in lymphocyte mass was not a prerequisite for the remission of pure red cell aplasia, and responses occurred within 1 month from the start of therapy. Clonal T-cell proliferation was detected in four patients, which raised the possibility of idiopathic pure red cell aplasia being associated with a clonal proliferation of T cells. An examination of the lymphocytes in patients with pure red cell aplasia could potentially be used to plan better therapeutic modalities and assess prognosis.
- Subjects
CYCLOSPORINE; LYMPHOCYTES; T cells; CELL proliferation
- Publication
British Journal of Haematology, 1999, Vol 106, Issue 2, p371
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.1999.01552.x