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- Title
Can mite-specific IgE be used as a surrogate for mite exposure?
- Authors
de Lovinfosse, S.; Charpin, D.; Dornelas, A.; Birnbaurn, J.; Vervloet, D.
- Abstract
Several epidemiologic studies suggest that in mite-sensitive patients symptoms are dependent upon mite-exposure level. However, in clinical practice, it is not easy to measure major mite allergens. In contrast, assay of specific IgE antibodies can be done routinely. Thus, we wanted to compare, in a group of 40 mite-sensitive patients, the levels of mite-specific IgE (measured by RAST grade 0-6) and the level of mite group I allergen in mattresses (measured in μg/g house dust). The correlation coefficient between both variables was highly significant (<em>P</em> = 0.001). Subjects with a RAST grade of 3 or more had a 77% probability of being exposed to high (i.e., > 10 μg/g dust) mite allergen level. In contrast, subjects with RAST grades 0, 1, or 2 had a 77% probability of not being exposed to such high levels. Thus, measurement of serum mite-specific IgE level could be used in routine prediction of mite exposure.
- Subjects
ALLERGENS; INFECTIOUS disease transmission; IMMUNOGLOBULIN E; ALLERGIES; EPIDEMIOLOGY; PUBLIC health
- Publication
Allergy, 1994, Vol 49, Issue 1, p64
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/j.1398-9995.1994.tb00776.x