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- Title
Synthetic GPI array to study antitoxic malaria response.
- Authors
Kamena, Faustin; Tamborrini, Marco; Xinyu Liu; Yong-Uk Kwon; Thompson, Fiona; Pluschke, Gerd; Seeberger, Peter H.
- Abstract
Parasite glycosylphosphatidylinositol (GPI) is an important toxin in malaria disease, and people living in malaria-endemic regions often produce high levels of anti-GPI antibodies. The natural anti-GPI antibody response needs to be understood to aid the design of an efficient carbohydrate-based antitoxin vaccine. We present a versatile approach based on a synthetic GPI glycan array to correlate anti-GPI antibody levels and protection from severe malaria.
- Subjects
MALARIA; ANTITOXINS; IMMUNOGLOBULINS; PROTOZOAN diseases; PREVENTIVE medicine
- Publication
Nature Chemical Biology, 2008, Vol 4, Issue 4, p238
- ISSN
1552-4450
- Publication type
Article
- DOI
10.1038/nchembio.75