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- Title
Drug-induced EEG pattern predicts effectiveness of ketamine in treating refractory status epilepticus.
- Authors
Basha, Maysaa M.; Alqallaf, Abdulradha; Shah, Aashit K.
- Abstract
Refractory status epilepticus ( RSE) can lack overt clinical manifestation and is usually treated with continuous infusion of intravenous anesthetic drugs ( IVADs), where the use of continuous electroencephalography (c EEG) is imperative. Ketamine has recently been shown to be effective in the treatment of RSE. We retrospectively review a cohort of 11 patients receiving ketamine as part of their treatment regimen for RSE. We report on the presence of a characteristic EEG rhythm consisting of a generalized archiform theta to beta rhythms (7-20 Hz) appearing after ketamine administration. This pattern was seen in five patients, four of whom achieved successful resolution of RSE. Ketamine-induced EEG pattern may serve as a biomarker predictive of successful treatment outcome in RSE.
- Subjects
KETAMINE; STATUS epilepticus; ANESTHETICS; INTRAVENOUS anesthetics; ELECTROENCEPHALOGRAPHY; THETA rhythm; BETA rhythm
- Publication
Epilepsia (Series 4), 2015, Vol 56, Issue 4, pe44
- ISSN
0013-9580
- Publication type
Article
- DOI
10.1111/epi.12947