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- Title
CYTOKINES AND T-LYMPHOCYTE COUNT IN PATIENTS IN THE ACUTE AND CHRONIC PHASES OF Bartonella bacilliformis INFECTION IN AN ENDEMIC AREA IN PERU: A PILOT STUDY.
- Authors
HUARCAYA, Erick; BEST, Ivan; RODRIGUEZ-TAFUR, Juan; MAGUIÑA, Ciro; SOLÓRZANO, Nelson; MENACHO, Julio; DE GUIMARAES, Douglas LOPEZ; CHAUCA, Jose; VENTOSILLA, Palmira
- Abstract
Human Bartonellosis has an acute phase characterized by fever and hemolytic anemia, and a chronic phase with bacillary angiomatosis-like lesions. This cross-sectional pilot study evaluated the immunology patterns using pre- and post-treatment samples in patients with Human Bartonellosis. Patients between five and 60 years of age, from endemic areas in Peru, in the acute or chronic phases were included. In patients in the acute phase of Bartonellosis a state of immune peripheral tolerance should be established for persistence of the infection. Our findings were that elevation of the anti-inflammatory cytokine IL-10 and numeric abnormalities of CD4+ and CD8+ T-Lymphocyte counts correlated significantly with an unfavorable immune state. During the chronic phase, the elevated levels of IFN-γ and IL-4 observed in our series correlated with previous findings of endothelial invasion of B. henselae in animal models.
- Subjects
PERU; BARTONELLA infections; CYTOKINES; VERRUGA peruana; HEMOLYTIC anemia; LYMPHOCYTES; ANIMAL models in research; PATIENTS
- Publication
Revista do Instituto de Medicina Tropical de São Paulo, 2011, Vol 53, Issue 3, p149
- ISSN
0036-4665
- Publication type
Article
- DOI
10.1590/S0036-46652011000300006