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- Title
Chemistry and Biology of Siderophores from Marine Microbes.
- Authors
Chen, Jianwei; Guo, Yuqi; Lu, Yaojia; Wang, Bixia; Sun, Jiadong; Zhang, Huawei; Wang, Hong
- Abstract
Microbial siderophores are multidentate Fe(III) chelators used by microbes during siderophore-mediated assimilation. They possess high affinity and selectivity for Fe(III). Among them, marine siderophore-mediated microbial iron uptake allows marine microbes to proliferate and survive in the iron-deficient marine environments. Due to their unique iron(III)-chelating properties, delivery system, structural diversity, and therapeutic potential, marine microbial siderophores have great potential for further development of various drug conjugates for antibiotic-resistant bacteria therapy or as a target for inhibiting siderophore virulence factors to develop novel broad-spectrum antibiotics. This review covers siderophores derived from marine microbes.
- Subjects
SIDEROPHORES; MICROORGANISMS; CHEMISTRY; DRUG development; BIOLOGY; CONJUGATED systems; QUORUM sensing; MARINE microbiology
- Publication
Marine Drugs, 2019, Vol 17, Issue 10, p562
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md17100562