We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Triglyceride to high-density lipoprotein cholesterol ratio as a predictor of long-term mortality in patients with coronary artery disease after undergoing percutaneous coronary intervention: a retrospective cohort study.
- Authors
Dai, Xin-Ya; Zheng, Ying-Ying; Tang, Jun-Nan; Yang, Xu-Ming; Guo, Qian-Qian; Zhang, Jian-Chao; Cheng, Meng-Die; Song, Feng-Hua; Liu, Zhi-Yu; Wang, Kai; Jiang, Li-Zhu; Fan, Lei; Yue, Xiao-Ting; Bai, Yan; Zhang, Zeng-Lei; Zheng, Ru-Jie; Zhang, Jin-Ying
- Abstract
Background: It has been confirmed that the triglyceride to high-density lipoprotein cholesterol ratio (THR) is associated with insulin resistance and metabolic syndrome. However, to the best of our knowledge, only a few studies with small sample sizes have investigated the relationship between THR and coronary artery disease (CAD). Therefore, we aimed to assess the correlation between the THR and long-term mortality in patients with CAD after undergoing percutaneous coronary intervention (PCI) in our study that enrolled a large number of patients. Methods: A total of 3269 post-PCI patients with CAD were enrolled in the CORFCHD-ZZ study from January 2013 to December 2017. The mean follow-up time was 37.59 ± 22.24 months. Patients were divided into two groups according to their THR value: the lower group (THR < 2.84, n = 1232) and the higher group (THR ≥ 2.84, n = 2037). The primary endpoint was long-term mortality, including all-cause mortality (ACM) and cardiac mortality (CM). The secondary endpoints were major adverse cardiac events (MACEs) and major adverse cardiac and cerebrovascular events (MACCEs). Results: In our study, ACM occurred in 124 patients: 30 (2.4%) in the lower group and 94 (4.6%) in the higher group (P = 0.002). MACEs occurred in 362 patients: 111 (9.0%) in the lower group and 251 (12.3%) in the higher group (P = 0.003). The number of MACCEs was 482: 152 (12.3%) in the lower group and 320 (15.7%) in the higher group (P = 0.008). Heart failure occurred in 514 patients: 89 (7.2%) in the lower group and 425 (20.9%) in the higher group (P < 0.001). Kaplan–Meier analyses showed that elevated THR was significantly related to long-term ACM (log-rank, P = 0.044) and the occurrence of heart failure (log-rank, P < 0.001). Multivariate Cox regression analyses showed that the THR was an independent predictor of long-term ACM (adjusted HR = 2.042 [1.264–3.300], P = 0.004) and heart failure (adjusted HR = 1.700 [1.347–2.147], P < 0.001). Conclusions: An increased THR is an independent predictor of long-term ACM and heart failure in post-PCI patients with CAD.
- Subjects
DRUG-eluting stents; PERCUTANEOUS coronary intervention; CORONARY disease; HIGH density lipoproteins; TRIGLYCERIDES; BLOOD cholesterol; HEART failure patients; METABOLIC syndrome
- Publication
Lipids in Health & Disease, 2019, Vol 18, Issue 1, pN.PAG
- ISSN
1476-511X
- Publication type
Article
- DOI
10.1186/s12944-019-1152-y