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- Title
Hypoglycemic Effect of Ethanol and Ethyl Acetate Extract of Phellinus baumii Fruiting Body in Streptozotocin-Induced Diabetic Mice.
- Authors
Wang, Wen-Han; Wu, Fei-Hua; Yang, Yan; Wu, Na; Zhang, Jing-Song; Feng, Na; Tang, Chuan-Hong
- Abstract
We investigated hypoglycemic effect of ethanol (EtOH) and ethyl acetate extract acetate (AcOEt) extracts in streptozotocin- (STZ-) induced diabetic mice. Our data showed the maximum inhibitory effect on the fasting plasma glucose (FPG) level was detected in STZ-induced diabetic mice administered with 400 mg/kg AcOEt extract of P. baumii. A lower glycated albumin (GA) level and a higher insulin level were observed in 400 mg/kg AcOEt and EtOH extract groups. Moreover, 400 mg/kg AcOEt and EtOH extract exhibited a stronger effect on increasing size and cell number of islets. The insulin expression level of β-cells and integrated optical density (IOD) value were significantly increased by the administration of 400 mg/kg AcOEt and EtOH extracts. Taken together, AcOEt and EtOH extracts of P. baumii fruiting body exhibited considerable hypoglycemic effect on STZ-induced diabetic mice.
- Subjects
AMINOGLYCOSIDES; ANIMAL experimentation; BLOOD sugar monitoring; DIABETES; ETHANOL; HYPOGLYCEMIC agents; INSULIN; ISLANDS of Langerhans; MEDICINAL plants; MICE; PLANT extracts; ALBUMINS
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2015, Vol 2015, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2015/783460