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- Title
Maternal and infant death after probable vertical transmission of chikungunya virus in Brazil - case report.
- Authors
Oliveira, Rhaquel de Morais Alves Barbosa; Barreto, Francisca Kalline de Almeida; Maia, Ana Maria Peixoto Cabral; Gomes, Ileana Pitombeira; Simião, Adriana Rocha; Barbosa, Rebeca Bandeira; Rodrigues, Adilina Soares Romeiro; Lopes, Kilma Wanderley; Araújo, Fernanda Montenegro de Carvalho; do Vale, Regina Lúcia Sousa; Cavalcante, John Washington; Cavalcanti, Luciano Pamplona de Góes
- Abstract
<bold>Background: </bold>Chikungunya virus infection in neonates is relatively rare and can lead to death.<bold>Case Presentation: </bold>We report the occurrence of the first death of a mother and child after probable vertical transmission of chikungunya virus in Brazil. A 28-year-old pregnant woman with hypertension presented with symptoms compatible with an arboviral disease at 34 weeks' gestation. She developed preeclampsia with severe respiratory failure which resulted in the emergency cesarean section, and the patient died 12 days after the onset of symptoms. The pre-term newborn weighed 2535 g, with an Apgar score of 4/8. He was referred to the neonatal ICU with neutrophilia and thrombocytopenia, several seizure episodes, and hemorrhagic disorders, which resulted in death. Chikungunya IgM antibody was detected in the cerebrospinal fluid.<bold>Conclusions: </bold>We present the first documented maternal and neonatal death in Brazil after probable chikungunya infection during pregnancy.
- Subjects
CHIKUNGUNYA virus; VERTICAL transmission (Communicable diseases); VIRUS disease transmission; ARBOVIRUS diseases; NEONATAL death; PREECLAMPSIA; HYPERTENSION in pregnancy; IMMUNOGLOBULIN M
- Publication
BMC Infectious Diseases, 2018, Vol 18, Issue 1, pN.PAG
- ISSN
1471-2334
- Publication type
journal article
- DOI
10.1186/s12879-018-3243-1