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- Title
Vasostatins Exert Negative Inotropism in the Working Heart of the Frog.
- Authors
CORTI, A.; MANNARINO, C.; MAZZA, R.; COLOMBO, B.; LONGHI, R.; TOTA, B.
- Abstract
A bstract: An in vitro isolated working frog heart ( Rana esculenta) was used to study the effects of exogenous CGA1-76 (vasostatin 1), CGA1-113 (vasostatin 2), and the synthetic CGA7-57 on cardiac performance. Under basal cardiac conditions, the dose-response curves of the three peptides from 10−8 to 10−7 M showed a significant calcium-dependent negative inotropism that involved neither the endocardial endothelium nor the adrenergic and muscarinic receptors. In addition, the CgA fragments clearly counteracted the typical positive inotropism of isoprenaline (10−<9 M). Taken together, these results provide the first evidence for a cardio-suppressive role for the vasostatins.
- Publication
Annals of the New York Academy of Sciences, 2002, Vol 971, Issue 1, p362
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.2002.tb04497.x