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- Title
A literature review of reports of the stability and storage of common injectable chemotherapy agents used in veterinary patients.
- Authors
Chan, C. M.; Frimberger, A. E.; Moore, A. S.
- Abstract
Many chemotherapy drugs used in human patients are discarded after single use or within 24 h of reconstitution, as per the manufacturer's product label recommendations. This can be wasteful and costly to veterinary clients. This report reviews the published stability and storage data for 19 injectable chemotherapy drugs commonly used in veterinary medicine. Based on these data, storage procedures are presented, assuming aseptic technique and a closed system drug transfer device ( CSDTD) are used for drug preparation and handling. Further studies on the risk of microbiological contamination of chemotherapeutics using a CSDTD, and validated high quality drug assays such as stability-indicating high-performance liquid chromatography, are required. The authors' intent is not to supersede product label recommendations, but to suggest that longer storage without significant loss of drug efficacy may be possible, thus reducing the costs of chemotherapeutics to some veterinary clients.
- Subjects
CANCER chemotherapy; VETERINARY oncology; VETERINARY medicine; DRUG labeling; EQUIPMENT &; supplies
- Publication
Veterinary & Comparative Oncology, 2017, Vol 15, Issue 4, p1124
- ISSN
1476-5810
- Publication type
Article
- DOI
10.1111/vco.12271