We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Catalytic Atropenantioselective Heteroannulation between Isocyanoacetates and Alkynyl Ketones: Synthesis of Enantioenriched Axially Chiral 3‐Arylpyrroles.
- Authors
Zheng, Sheng‐Cai; Wang, Qian; Zhu, Jieping
- Abstract
We report herein the first examples of catalytic enantioselective synthesis of axially chiral 3‐arylpyrroles. Reaction of α‐isocyanoacetates with β‐aryl‐α,β‐alkynic ketones in the presence of silver oxide and a phosphine ligand derived from Cinchona alkaloid occurred chemoselectively to afford enantioenriched 3‐arylpyrroles in high yields with excellent enantiomeric excesses. The pyrrole ring was constructed de novo in this process.
- Subjects
SILVER oxide; CINCHONA alkaloids; NATURAL products; ATROPISOMERS; PYRROLES
- Publication
Angewandte Chemie, 2019, Vol 131, Issue 5, p1508
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201812654