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- Title
Gold-Triggered Uncaging Chemistry in Living Systems.
- Authors
Pérez ‐ López, Ana M.; Rubio ‐ Ruiz, Belén; Sebastián, Víctor; Hamilton, Lloyd; Adam, Catherine; Bray, Thomas L.; Irusta, Silvia; Brennan, Paul M.; Lloyd ‐ Jones, Guy C.; Sieger, Dirk; Santamaría, Jesús; Unciti ‐ Broceta, Asier
- Abstract
Recent advances in bioorthogonal catalysis are increasing the capacity of researchers to manipulate the fate of molecules in complex biological systems. A bioorthogonal uncaging strategy is presented, which is triggered by heterogeneous gold catalysis and facilitates the activation of a structurally diverse range of therapeutics in cancer cell culture. Furthermore, this solid-supported catalytic system enabled locally controlled release of a fluorescent dye into the brain of a zebrafish for the first time, offering a novel way to modulate the activity of bioorthogonal reagents in the most fragile and complex organs.
- Subjects
CATALYSIS; BIOLOGICAL systems; GOLD catalysts; CANCER cells; CELL culture
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 41, p12722
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201705609